Aquisinoids A and B: Two New Sesquiterpenoid‐Benzaldehyde Hybrids From Aquilaria Sinensis

Chemistry & Biodiversity 2026

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Authors: Li‐Fen Ma, Rong Huang, Zhen-Zhou Han, De‐an Guo, Wei Li
DOI: 10.1002/cbdv.71113
Cited by: 0
References: 19

Abstract

ABSTRACT Two previously undescribed sesquiterpenoid‐benzaldehyde hybrids, aquisinoids A ( 1 ) and B ( 2 ), were isolated from agarwood of Aquilaria sinensis . Their structures were elucidated by comprehensive spectroscopic data analysis, single‐crystal x‐ray diffraction, and electronic circular dichroism calculations. Structurally, both compounds feature a polycyclic core formed by connecting a prezizaane‐type sesquiterpenoid unit with a p ‐hydroxybenzaldehyde moiety via a 1,3‐dioxolane bridge. Compounds 1 and 2 exhibited moderate inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)‐induced RAW 264.7 macrophages, with IC 50 values of 22.4 and 26.7 µM, respectively.

Fields of Study & Subjects

Wood and Agarwood Research Natural Compound Pharmacology Studies Marine Sponges and Natural Products

Publication details

Journal / source
Chemistry & Biodiversity
Volume
23
Issue
3
Pages
e71113–e71113
Publication date
1 March 2026
Language
EN