Design, Synthesis, and Bioevaluation of Adamantane‐1‐Carboxamide N‐Acylthioureas for Airway Antiallergic Therapy

Airway epithelial cells (AECs) serve as the first line of defense against environmental pollutants, with exposure to traffic‐related particles known to exacerbate allergic asthma. In this study, a series of adamantane‐containing N‐acylthiourea compounds are designed, synthesized, and structurally characterized by 1 H NMR, 13 C NMR, HR‐ESI‐MS, FT‐IR, and UV–vis spectroscopy. Among them, compound AD3 , is crystallized in the triclinic P‐1 space group. Here, it is found that AD4 upregulated the expression of protein phosphatase 4 (PP4) in BEAS‐2B airway epithelial cells in a concentration‐dependent manner. AD4 treatment also significantly restored epithelial barrier integrity and suppressed the production of thymic stromal lymphopoietin (TSLP) production challenged by diesel exhaust particles (DEP). To the author's knowledge, this represents the first report identifying AD4 as a potential therapeutic agent for allergic asthma, highlighting a novel strategy for antiallergic drugs.