Left Bundle Branch Area Pacing for Cardiac Amyloidosis With Ser43Asn Mutant Transthyretin: A Case Report

Catheterization and Cardiovascular Interventions 2026 Open access

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Authors: Fengyou Yao, Denghong Zhang, Zhi Yang, Guyue Liu, P. Wang, Jingjing Hu, Junqi Gou
DOI: 10.1002/ccd.70505
Cited by: 0

Abstract

Hereditary transthyretin (TTR) cardiac amyloidosis is a rare infiltrative cardiomyopathy. Involvement of the cardiac conduction system may lead to atrioventricular block. Left bundle branch area pacing (LBBAP) represents an emerging pacing strategy. We report a case of hereditary TTR amyloidosis with 2:1 atrioventricular block (second-degree), a wide QRS escape rhythm, and reduced ejection fraction, in which LBBAP improved symptoms and hemodynamic parameters. To our knowledge, this is the first documented case of Ser43Asn TTR amyloidosis managed with LBBAP.

Fields of Study & Subjects

Amyloidosis: Diagnosis Treatment Outcomes Cardiac pacing and defibrillation studies Cardiac electrophysiology and arrhythmias

Publication details

Journal / source
Catheterization and Cardiovascular Interventions
Volume
107
Issue
5
Pages
1437–1440
Publication date
8 February 2026
Language
EN