Drug‐Resistant Sinus Tachycardia as a Dose‐Dependent Side Effect of Spironolactone: A Case Report and Review of the Literature

Clinical Case Reports 2026 Open access

Read full text
Authors: Zahra Abdi, Maryam Chenaghlou, Aysa rezabakhsh, Laya Hooshmand Gharabagh
DOI: 10.1002/ccr3.71875
Cited by: 1
References: 21

Abstract

Spironolactone is widely used for polycystic ovarian syndrome due to its anti-androgenic properties. However, rare cardiovascular side effects may occur even in normotensive patients. We report a case of severe palpitations and drug-resistant sinus tachycardia following high-dose therapy, emphasizing the need for cautious titration and cardiac monitoring.

Fields of Study & Subjects

Cardiovascular Syncope and Autonomic Disorders Pathogenesis and Treatment of Hiccups Hormonal and reproductive studies

Publication details

Journal / source
Clinical Case Reports
Publisher
Wiley
Volume
14
Issue
2
Pages
e71875–e71875
Publication date
1 February 2026
Language
EN