Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4 ‐Linked Hereditary Spastic Paraplegia—A Case Report

Clinical Case Reports 2026 Open access

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Authors: Ziad W. Elmezayen, Hossam Salameh, Asem Afana, Anwar Zahran
DOI: 10.1002/ccr3.71884
Cited by: 0
References: 23

Abstract

In a patient with genetically confirmed SPG4-linked hereditary spastic paraplegia, initiation of allopurinol for asymptomatic hyperuricemia led to rapid and sustained improvement in lower limb spasticity, allowing marked reduction of antispasmodic therapy. This serendipitous finding suggests a potential therapeutic role of xanthine oxidase inhibition in managing HSP-related spasticity.

Fields of Study & Subjects

Hereditary Neurological Disorders Botulinum Toxin and Related Neurological Disorders Genetic Neurodegenerative Diseases

Publication details

Journal / source
Clinical Case Reports
Volume
14
Issue
1
Pages
e71884–e71884
Publication date
1 January 2026
Language
EN