Acquired Coagulation Factor XIII Deficiency With Spontaneous Splenic Rupture: A Case Report
Abstract
Coagulation factor XIII deficiency (FXIIID) is a rare hemorrhagic disease, mainly manifested as skin ecchymosis and hematoma. Because of its atypical clinical manifestations and normal results of routine coagulation test, platelet count and function, it has brought great challenges to the diagnosis. This case report introduces the diagnosis and treatment of an elderly male patient with FXIIID in detail, and aims to emphasize the necessity of detecting FXIII activity when spontaneous bleeding occurs in patients with normal routine coagulation function and platelet count. At the same time, it emphasizes the importance of etiology finding and individualized treatment and management for patients with FXIIID.
Fields of Study & Subjects
Blood properties and coagulation
Hemophilia Treatment and Research
Coagulation
Bradykinin
Polyphosphates
and Angioedema
Publication details
- Journal / source
- Clinical Case Reports
- Volume
- 14
- Issue
- 2
- Pages
- e72030–e72030
- Publication date
- 1 February 2026
- Language
- EN