Metoclopramide‐Induced Pheochromocytoma Crisis: A Case Report and Literature Review

Clinical Case Reports 2026 Open access

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Authors: Yuki Yamanishi, Kazuki Iio, Keiki Shimizu, Wataru Kasahara, Jun Hamaguchi
DOI: 10.1002/ccr3.72144
Cited by: 1
References: 24

Abstract

Pheochromocytoma is a catecholamine-secreting neuroendocrine tumor originating in the adrenal medulla. In patients with pheochromocytoma, paroxysmal over-secretion of catecholamines can be triggered by various medications, including the commonly used antiemetic metoclopramide. We report herein a fatal case of pheochromocytoma crisis triggered by metoclopramide and present a literature review of metoclopramide-induced pheochromocytoma crises to elucidate their clinical characteristics.

Fields of Study & Subjects

Adrenal and Paraganglionic Tumors Nausea and vomiting management Cardiovascular Syncope and Autonomic Disorders

Publication details

Journal / source
Clinical Case Reports
Publisher
Wiley
Volume
14
Issue
3
Pages
e72144–e72144
Publication date
26 February 2026
Language
EN