Breathless and Beyond: Anterior Mediastinal Malignant Peripheral Nerve Sheath Tumor as a Rare Neurofibromatosis Type 1 Manifestation

Clinical Case Reports 2026 Open access

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Authors: Muhammad Hassan Raza, Hamza Asif, Sadia Anjum, Zaira Shahid, Moosa Mubarika, Abdulsattar Anjum, Hassan Abdullah Shakeel, Rejina Chhetri, Muneeb Khawar
DOI: 10.1002/ccr3.72184
Cited by: 0
References: 12

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) can rarely present as anterior mediastinal masses in patients with neurofibromatosis type 1 (NF1), causing respiratory symptoms and diagnostic challenges. Multidisciplinary evaluation, including biopsy and imaging, is essential for diagnosis, with surgical resection as the primary treatment. Early recognition and vigilant monitoring in NF1 patients are crucial for prompt intervention and improved outcomes.

Fields of Study & Subjects

Neurofibromatosis and Schwannoma Cases Soft tissue tumor case studies Neuroblastoma Research and Treatments

Publication details

Journal / source
Clinical Case Reports
Volume
14
Issue
3
Pages
e72184–e72184
Publication date
1 March 2026
Language
EN