Successful Treatment of Cutaneous Squamous Cell Carcinoma Complicated by Myelodysplastic Syndrome Using Combined ALA ‐ PDT and Narrow‐Margin Excision: A Case Report
Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer. When the cSCC patient is complicated by myelodysplastic syndromes (MDS), treatment becomes particularly challenging due to immunosuppression, bleeding risk, and poor tolerance to conventional therapies. Here, we report a case of a 77-year-old woman with cSCC and MDS who was successfully treated by a combination of narrow-margin surgical excision and 5-aminolevulinic acid photodynamic therapy (ALA-PDT). No recurrence was observed during a six-month follow-up. This approach may offer a valuable therapeutic option for similar high-risk cSCC patients.
Fields of Study & Subjects
Nonmelanoma Skin Cancer Studies
Head and Neck Cancer Studies
Cancer and Skin Lesions
Publication details
- Journal / source
- Clinical Case Reports
- Volume
- 14
- Issue
- 3
- Pages
- e72256–e72256
- Publication date
- 1 March 2026
- Language
- EN