Acute Systemic Complications Following High‐Dose Semaglutide Reinitiation in an Elderly Patient
Abstract
Severe gastrointestinal intolerance with systemic complications can occur within hours of reinitiating high-dose semaglutide after a prolonged treatment interruption, even in patients who previously tolerated the medication. Elderly patients with comorbidities may be particularly vulnerable. Clinicians should consider re-titration from lower doses when restarting GLP-1 receptor agonists after drug holidays to minimize severe adverse effects.
Fields of Study & Subjects
Diabetes Treatment and Management
Hyperglycemia and glycemic control in critically ill and hospitalized patients
Diet and metabolism studies
Publication details
- Journal / source
- Clinical Case Reports
- Publisher
- Wiley
- Volume
- 14
- Issue
- 5
- Pages
- e72356–e72356
- Publication date
- 23 April 2026
- Language
- EN