Life‐Threatening Acute Tumor Lysis Syndrome With Multiorgan Failure Following First Cycle of Bendamustine–Rituximab in Chronic Lymphocytic Leukemia: A Case Report and Brief Review

Clinical Case Reports 2026 Open access

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Authors: Malegna Temesgen Garuma, Kebede H. Begna, Tesfaye Belete Amare, Mengisteab Kassahun Desta, Derebe Shashigo Leilago, Humud Mohammed Ahmed
DOI: 10.1002/ccr3.72548
Cited by: 1
References: 8

Abstract

Chronic lymphocytic leukemia is not uniformly low risk for tumor lysis syndrome. This case shows that first-cycle bendamustine-rituximab in patients with high disease burden can precipitate severe TLS with acute kidney injury and multiorgan failure. Individualized prophylaxis, patient education, and close monitoring during early therapy are essential.

Fields of Study & Subjects

Methemoglobinemia and Tumor Lysis Syndrome Acute Lymphoblastic Leukemia research Chronic Lymphocytic Leukemia Research

Publication details

Journal / source
Clinical Case Reports
Publisher
Wiley
Volume
14
Issue
4
Pages
e72548–e72548
Publication date
1 April 2026
Language
EN