Acute Drug‐Induced Liver Injury After Four Doses of Nitrofurantoin, as Evaluated for Causality Using the Updated RUCAM , With a Disproportionate Rise in AST —A Novel Case Report
Abstract
Drug-induced liver injury remains a severe but underdiscussed adverse effect of nitrofurantoin. This case uniquely describes hepatic injury occurring after four doses of nitrofurantoin, with a disproportionate rise in AST and rapid complete recovery following discontinuation of the drug. A RUCAM score of six supports the probability of DILI.
Fields of Study & Subjects
Drug-Induced Hepatotoxicity and Protection
Inflammatory mediators and NSAID effects
Urinary Tract Infections Management
Publication details
- Journal / source
- Clinical Case Reports
- Publisher
- Wiley
- Volume
- 14
- Issue
- 7
- Pages
- e73021–e73021
- Publication date
- 23 June 2026
- Language
- EN