Pembrolizumab‐Associated Serositis With Recurrent Pleural Effusions Successfully Treated With Anakinra

Clinical Case Reports 2026 Open access

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Authors: Emma MCNALLY, Sean Garvey, Malcolm Herron, Niall Conlon, Sinead Cuffe, R C Conway, Laura Gleeson
DOI: 10.1002/ccr3.73112
Cited by: 1
References: 6

Abstract

Immune checkpoint inhibitor-associated serositis is rare and may present with recurrent effusions. Some cases are steroid dependent, contributing to significant toxicity for patients. Guidance on steroid-sparing therapy is limited. Our case describes IL-1 blockade with anakinra which was well tolerated and effective, supporting its use as a steroid-sparing option.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Spondyloarthritis Studies and Treatments IgG4-Related and Inflammatory Diseases

Publication details

Journal / source
Clinical Case Reports
Publisher
Wiley
Volume
14
Issue
7
Pages
e73112–e73112
Publication date
1 July 2026
Language
EN