Hydroxyalkylation of Benzylic C─H Bonds via Heterogeneous Photocatalysis

ChemCatChem 2026 Open access

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Authors: Pengfei Song, Mengyao Yuan, Xinyuan He, Zhigang Chai
DOI: 10.1002/cctc.202501652
Cited by: 3
References: 15

Abstract

ABSTRACT Hydroxyalkylation of benzylic C─H bonds with alcohol can not only construct C(sp 3 )─C(sp 3 ) bonds but also introduce hydroxyl groups into the organic scaffold, which offers an efficient and straightforward approach to access versatile benzylic moieties. Here we disclose a protocol of hydroxyalkylation of benzylic C─H bonds enabled by the hydrogen bonding‐assisted cage effect (HBACE). A broad scope of benzylic C─H substrates can be converted into desired products with excellent selectivity. The transformation follows a radical cross‐coupling mechanism which may be dominated by the persistent radical effect.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Oxidative Organic Chemistry Reactions

Publication details

Journal / source
ChemCatChem
Publisher
Wiley
Volume
18
Issue
1
Publication date
1 January 2026
Language
EN