Ligandless Iron‐Catalyzed C(sp 3 )─H Bond Fluorination
Abstract
ABSTRACT Iron(II) triflate, Fe(OTf) 2 (OTf = CF 3 SO 3 − ) has been used as a catalyst for directing group‐free intermolecular C(sp 3 )─H fluorination in the absence of any added ligand. This transformation proceeds under mild conditions with low catalyst loading utilizing Selectfluor as the fluorine source. Reaction conditions were optimized, a range of substrates were evaluated, and the functional group tolerance of the fluorination strategy was systematically investigated. A plausible catalytic cycle is proposed based on the results of control experiments.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- ChemCatChem
- Volume
- 18
- Issue
- 1
- Publication date
- 1 January 2026
- Language
- EN