Electrochemical Hofmann Rearrangement to Hydrazides

ChemElectroChem 2026 Open access

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Authors: Zeyu Feng, Darryl F. Nater, Tonin Léautier, Matthieu Sintes, Thomas Weyhermüller, Siegfried R. Waldvogel
DOI: 10.1002/celc.70151
Cited by: 1
References: 69

Abstract

We present the first electrochemical Hofmann rearrangement for the sustainable and safe synthesis of N , N ‐disubstituted hydrazides from readily available ureas. The process employs a simple undivided‐cell set‐up with LiCl as a low‐cost, environmentally benign supporting electrolyte and operates efficiently at high current density up to 120 mA/cm 2 . This strategy accommodates a broad substrate scope with 36 examples and yields up to 84%. Additionally, the method was found to be both applicable and scalable for pharmaceutically relevant compounds.

Fields of Study & Subjects

Radical Photochemical Reactions Ammonia Synthesis and Nitrogen Reduction Catalytic Cross-Coupling Reactions

Publication details

Journal / source
ChemElectroChem
Publisher
Wiley
Volume
13
Issue
4
Publication date
17 February 2026
Language
EN