Magnesium(I)‐Mediated Dearomatizing Coupling of Pyridines and Subsequent Hydrogen Transfer Reactions

Chemistry - A European Journal 2026

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Authors: Zhenzhou Sun, Luomo Li, Lei Yang, Shi‐Lu Chen, Xueping Yang, Biao Wu, Xiao‐Juan Yang
DOI: 10.1002/chem.202503394
Cited by: 1
References: 60

Abstract

) can promote reductive 4,4'-homocoupling of pyridine and derivatives under ambient conditions, yielding the 4,4'-dihydro-4,4'-bipyridinate products 2-6. Interestingly, these species can be viewed as "dimerized" metal-1,4-dihydropyridinates (bis-M-DHPs) and can transfer hydrogen or deuterium (as proton and hydride) to pyridines, imines and alkenes. This may provide a facile access to new H/D-donors, readily obtained from commercially available pyridines and a conveniently synthesized magnesium(I) complex, for controllable H-transfer (HT) to different types of unsaturated molecules. The coupling and HT mechanisms were elucidated by DFT calculations.

Fields of Study & Subjects

Coordination Chemistry and Organometallics Organometallic Complex Synthesis and Catalysis Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Chemistry - A European Journal
Publisher
Wiley
Volume
32
Issue
11
Pages
e03394–e03394
Publication date
15 January 2026
Language
EN