Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis
Abstract
Mechanochemistry has attracted significant attention as a sustainable and efficient alternative to solution-based synthesis, offering the advantage of solvent-free conditions or the use of only minor amounts of solvent. Many established mechanochemical transformations rely on the use of additives-a strategy broadly referred to as additive-assisted grinding. The most employed additives are liquids (liquid-assisted grinding (LAG)), ionic solids, and non-ionic additives. Additionally, ionic liquids (ionic liquid-assisted grinding (IL-AG)), piezoelectric, or mechanoluminescent materials can be used. This review provides an overview of additive-assisted organic synthetic transformations under mechanochemical conditions, highlighting the roles, advantages, and limitations of additives, as well as emerging trends from recent literature.
Fields of Study & Subjects
Crystallography and molecular interactions
Ionic liquids properties and applications
Force Microscopy Techniques and Applications
Publication details
- Journal / source
- Chemistry - A European Journal
- Publisher
- Wiley
- Volume
- 32
- Issue
- 9
- Pages
- e03536–e03536
- Publication date
- 5 January 2026
- Language
- EN