Alkene Functionalizations via the Alkenyl Catellani Reaction
Abstract
Palladium/norbornene (Pd/NBE) cooperative catalysis is widely regarded as an effective strategy for constructing polysubstituted arenes, providing a rapid and efficient route that is often difficult to accomplish using traditional cross-coupling methods. This review focuses on applying Pd/NBE cooperative catalysis to the functionalization of nonaromatic systems, referred to as the alkenyl Catellani reaction. The nonaromatic substrates discussed include uracil, 2-quinolone, 2-pyridone, alkene, coumarin, chromone, glycal, and 1,2-azaborine, all of which generate a broad range of functional alkenes. In addition, this review outlines developments in asymmetric alkenyl Catellani reactions and highlights their use in the total synthesis of structurally complex molecules.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Chemistry - A European Journal
- Publisher
- Wiley
- Volume
- 32
- Issue
- 9
- Pages
- e03561–e03561
- Publication date
- 7 January 2026
- Language
- EN