Copper‐Catalyzed Umpolung Strategy of N ‐2,2,2‐Trifluoroethylisa‐tin Ketimines for the Synthesis of Spirobenzodiazepine Oxindoles
Abstract
A copper-catalyzed umpolung [4+3] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with ethynyl benzoxazinanones is reported, featuring rare Cα-selective nucleophilic reactivity of the ketimine (overcoming the typical predominance of Cα'-position). This protocol affords 1,3-benzodiazepines embedded with a spirooxindole scaffold in high yields and excellent diastereoselectivities, with broad substrate scope and good functional group tolerance. The products integrate pharmacophoric 1,3-benzodiazepine, spirooxindole, and trifluoromethyl moieties, holding promise for drug discovery.
Fields of Study & Subjects
Synthesis and pharmacology of benzodiazepine derivatives
Fluorine in Organic Chemistry
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Chemistry - A European Journal
- Volume
- 32
- Issue
- 19
- Pages
- e00001–e00001
- Publication date
- 4 March 2026
- Language
- EN