Front Cover: Evolved DNAzymes and Stable Activation Chemistry Enable High‐Efficiency DNA Ligation
Abstract
The Front Cover shows the process of in vitro selection to create more efficient DNA-ligating DNAzymes. As they explain in their Research Article (DOI: 10.1002/chem.202502788), using a pre-structured library derived from an existing DNAzyme, Y. Li and co-workers performed ten rounds of in vitro selection and discovered new DNAzymes with enhanced DNA-ligation activity. Through a complementary chemical screening approach, they also developed more stable DNA substrates, improving the overall efficiency and robustness of DNA ligation, a critical process for applications such as digital DNA data storage.
Fields of Study & Subjects
Advanced biosensing and bioanalysis techniques
DNA and Biological Computing
DNA and Nucleic Acid Chemistry
Publication details
- Journal / source
- Chemistry - A European Journal
- Volume
- 32
- Issue
- 6
- Publication date
- 9 February 2026
- Language
- EN