Iodoform‐Mediated Radical Iodinative Amidation Toward γ ‐Lactam

Chemistry - A European Journal 2026

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Authors: Mengyan Gao, Rui Yang, Linyang Jiang, Pengpeng Zhu, Tong Liu, Huaguang Yu, Yun-Hee Han, Hong Hou, Shaoqun Zhu
DOI: 10.1002/chem.71252
Cited by: 1
References: 50

Abstract

We herein report a visible light photochemical radical iodinative amidation protocol by the utilization of iodoform as the iodine atom source and unsaturated carboxylic acid derived secondary amide as the substrate. The iodine atom was generated by the homolytic cleavage of a C─I bond of iodoform and initiated a cascade transformation toward γ-lactam derivatives. Compared with previous di-functionalization approach for the synthesis of γ-lactams, the present protocol with the advantages of high functional group tolerance, simple reaction conditions, as well as without transition metal requirement.

Fields of Study & Subjects

Radical Photochemical Reactions Advanced Synthetic Organic Chemistry Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Chemistry - A European Journal
Publisher
Wiley
Volume
32
Issue
36
Pages
e71252–e71252
Publication date
8 June 2026
Language
EN