Photoexcited Nickel(0)‐Catalyzed Direct Decarboxylative Cross‐Coupling
Abstract
Decarboxylative coupling is a key strategy for C─C bond formation in modern synthesis. Despite the abundance and diversity of natural amino acids, their direct decarboxylation remains challenging. Here, we report the direct decarboxylation of amino acids to generate α-aminocarbon radicals and their subsequent cross-coupling, enabled by air-stable nickel(0) complexes under photoexcitation without external photosensitizers. This mild catalytic system shows broad compatibility with diverse amino acids and aromatic functional groups, providing a new approach for their direct decarboxylation and functionalization.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
CO2 Reduction Techniques and Catalysts
Publication details
- Journal / source
- Chemistry - A European Journal
- Publisher
- Wiley
- Volume
- 32
- Issue
- 38
- Pages
- e71312–e71312
- Publication date
- 27 June 2026
- Language
- EN