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Abstract

An efficient variant of the venerable Fischer indole synthesis featuring the direct use of carboxylic acids as aldehyde surrogates was developed. The utility of this protocol was demonstrated by the one‐pot synthesis of a series of 3‐substituted indoles and 3,5‐, 3,6‐, 3,7‐disubstituted derivatives. This work would inspire chemists to develop other non‐decarboxylative transformations of carboxylic acids. More details are discussed in the article by Huang et al . on pages 795—803. image

Fields of Study & Subjects

Synthesis of Indole Derivatives Synthesis and bioactivity of alkaloids Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Chinese Journal of Chemistry
Volume
44
Issue
6
Pages
761–761
Publication date
15 February 2026
Language
EN