Front Cover: Terrific Twenty—Celebrating ChemMedChem’s 20th Anniversary in 2026

This 2026, ChemMedChem turns 20! Our Anniversary Cover celebrates the traditional and the new. Our signature yellow, reminiscent of our predecessor Italian journal Il Farmaco, represents the journal’s beginnings and core content of traditional medicinal chemistry. The ribbon model of a GPCR represents the future of drug discovery and therapeutics—from computational methods to novel therapeutic modalities. This is all framed by a more abstract, artistic rendering of a protein structure, reminding us that while computational models and AI surround us, human creativity and insight are more important than ever. Like the painting, science can be messy and unexpected, but overall, still a beautiful human endeavor. Finally, two additional colors represent our key partners. Blue-green is for our sister journal ChemBioChem, with whom we work closer than ever before. Dark blue is for the European Federation for Medicinal Chemistry and Chemical Biology (EFMC), for which we serve as an official journal. Watch out for more information about the journal’s history and anniversary activities in upcoming Editorials throughout the year. Cover art by Robert de Angelo A. Bolinas.