Front Cover: Functional Proteomics of Quinazolin‐4‐One Derivatives Targeting the Proteasome (ChemMedChem 2/2026)

ChemMedChem 2026

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Authors: Elva Morretta, Claudia Finamore, Rosa Barbato, Simona De Marino, Ivana Bello, Elisabetta Panza, Matteo Mozzicafreddo, Angela Zampella, Carmen Festa, Maria Chiara Monti
DOI: 10.1002/cmdc.70223
Cited by: 0

Abstract

This cover shows the quinazolinone 4k approaching 26S proteasome, as discovered by limited proteolysis-based functional proteomics. Its interacting partners, the 20S β2 and β5 subunits, are depicted in white and light blue, respectively. The resulting inhibition of β5 chymotrypsin-like activity results in 4k cytotoxicity, represented by the green living cells turning into red, dying ones. More details can be found in the Research Article by Carmen Festa, Maria Chiara Monti, and co-workers (DOI: 10.1002/cmdc.202500728).

Fields of Study & Subjects

Ubiquitin and proteasome pathways Quinazolinone synthesis and applications Protein Degradation and Inhibitors

Publication details

Journal / source
ChemMedChem
Volume
21
Issue
2
Publication date
1 January 2026
Language
EN