Formal Total Synthesis of Daphnenoid A

ChemPlusChem 2026

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Authors: Chi Zhang, Kunhong Long, Renfeng Qiao, Yahui Ding, Yue Chen, Liang Wang
DOI: 10.1002/cplu.202500703
Cited by: 0
References: 27

Abstract

A formal total synthesis of 5/5/5/6 caged-like daphnenoid A was accomplished. The strategy involves a Morita-Baylis-Hillman reaction to construct a precursor for the key intramolecular Diels-Alder reaction (IMDA). Notably, the IMDA indicated opposite chemoselectivity when the configuration of stereocenter (C7) changed. Several intermediates we synthesized showed stronger anti-inflammation activities compared to daphnenoid A.

Fields of Study & Subjects

Biological Activity of Diterpenoids and Biflavonoids Advanced Synthetic Organic Chemistry Organic Chemistry Synthesis Methods

Publication details

Journal / source
ChemPlusChem
Volume
91
Issue
1
Pages
e202500703–e202500703
Publication date
1 January 2026
Language
EN