Strengthening Pharmacovigilance Reporting for Withdrawal Reactions to Support Deprescribing
Abstract
Pharmacovigilance plays a crucial role in post-marketing surveillance of medicines and relies on the spontaneous reporting of adverse drug reactions (ADRs). Discontinuation of a drug can cause clinically relevant signs and symptoms, including withdrawal reactions; however, this subset of ADRs is not fully accommodated in current pharmacovigilance practice. We discuss proposed revisions to current ADR forms that could enhance the capture of withdrawal reaction evidence.
Fields of Study & Subjects
Pharmacovigilance and Adverse Drug Reactions
Meta-analysis and systematic reviews
Drug-Induced Adverse Reactions
Publication details
- Journal / source
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Volume
- 120
- Issue
- 3
- Pages
- 663–666
- Publication date
- 6 June 2026
- Language
- EN