Factors associated with discordant visual and quantitative amyloid PET results

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring 2026 Open access

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Authors: Jasmin E. Guevara, Emily F. Matusz, Wei‐En Wang, Jesse C. DeSimone, Batul A. Yawer, Jacob Fiala, S. Levy, Franchesca Arias, Sruti Rayaprolu, Warren W Barker, Michael M Marsiske, Rosie E Curiel Cid
+9 more Steven T DeKosky, Nikolaus R. McFarland, Melissa J Armstrong, Malek Adjouadi, David E. Vaillancourt, G.J.W. Smith, David A Loewenstein, Ranjan Duara, Breton M. Asken
DOI: 10.1002/dad2.70241
Cited by: 2
References: 44

Abstract

Abstract INTRODUCTION Factors underlying discordant visual and quantitative amyloid beta–positron emission tomography (Aβ‐PET) results and their clinical implications are not well understood. METHODS Participants from the 1Florida Alzheimer's Disease Research Center (1FLADRC) underwent Aβ‐PET, blood draw, brain magnetic resonance imaging (MRI), and neuropsychological testing. We evaluated differences in demographics, apolipoprotein E ( APOE ) status, biomarkers, and cognition among older adults with concordant and discordant visual‐quantitative Aβ‐PET. Discordance was defined as positive visual read (V) of Aβ‐PET with below‐threshold Centiloid quantification (Q; CL

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Schizophrenia research and treatment

Publication details

Journal / source
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Publisher
Wiley
Volume
18
Issue
1
Pages
e70241–e70241
Publication date
1 January 2026
Language
EN