Detection and Longitudinal Monitoring of Cyclosporine in Horse Plasma and Urine After Ocular Implant Administration

Drug Testing and Analysis 2026

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Authors: Yat‐Ming So, Wai Him Kwok, Charlynn Yap, Celia O. L. Wong, Samuel G. R. Smalley, B. Forbes, Derek W. Y. Chow, Emmie N. M. Ho
DOI: 10.1002/dta.70026
Cited by: 1
References: 13

Abstract

This paper describes the detection and longitudinal monitoring of cyclosporine in plasma and urine after subconjunctival implant administration in a horse. Sensitive liquid chromatography tandem mass spectroscopy (LC-MS/MS) methods for detecting cyclosporine in horse plasma and urine have been developed and validated, with estimated limits of detection down to 1 pg/mL in both matrices. The developed methods enabled longitudinal monitoring of cyclosporine levels in blood and urine samples collected over 6 months from a horse that had received an ocular cyclosporine implant.

Fields of Study & Subjects

Ocular Disorders and Treatments Renal Transplantation Outcomes and Treatments Intraocular Surgery and Lenses

Publication details

Journal / source
Drug Testing and Analysis
Publisher
Wiley
Volume
18
Issue
3
Pages
376–382
Publication date
18 January 2026
Language
EN