Impact of Monacolin K‐Containing Supplements on Lipid Profile: A Meta‐Analysis of Randomised Controlled Trials

BACKGROUND: Natural products have gained attention as alternative strategies for managing dyslipidemia, particularly in individuals who are resistant or unwilling to use conventional pharmacotherapies. Monacolin K, a compound derived from natural sources, has demonstrated potential benefits in improving lipid profile indices across various doses and supplementation durations. This study aimed to quantitatively evaluate the effects of monacolin K-containing products on plasma lipid levels through a meta-analysis of clinical trials. METHODS: Data were extracted from studies that included placebo or inactive control groups, and the analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. RESULTS: Our findings indicate that monacolin K-containing supplements are effective in lowering lipid levels, particularly low-density lipoprotein cholesterol (LDL-C). CONCLUSION: These results highlight the potential of monacolin K as a promising adjunct therapy for hypercholesterolemia management, especially for patients who have not achieved LDL-C targets with standard care or are intolerant to or unwilling to use statin therapy.