A Cell‐Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus

European Journal of Immunology 2026 Open access

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Authors: Zoe‐Isabella Junginger, Ramona Adameck, Alexandre A. S. F. Raposo, Pedro Rosmaninho, Ana E. Sousa, Afonso R. M. Almeida
DOI: 10.1002/eji.70132
Cited by: 1
References: 9

Abstract

We identified RANK (TNFRSF11a) expression in human thymic FOXP3+ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4+ tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) https://BioRender.com/gbrjlpa.

Fields of Study & Subjects

Immune Cell Function and Interaction T-cell and B-cell Immunology NF-κB Signaling Pathways

Publication details

Journal / source
European Journal of Immunology
Publisher
Wiley
Volume
56
Issue
2
Pages
e70132–e70132
Publication date
1 February 2026
Language
EN