Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics
Abstract
Spatial transcriptomics allows for the investigation of complex cellular ecosystems directly in their native tissues and enables the dissection of immune niches as spatially organized and functionally diverse microenvironments across homeostatic, inflammatory, and malignant settings. In this review, we examine how spatial transcriptomics tools have been applied to interrogate the cellular and molecular architecture of immune niches, including the emerging studies of B and T cell clonal niches. We focus on immune niches in intestinal and tumor tissues due to their importance to both health and pathology, discuss pressing immunological questions these technologies may help to address, and highlight future developments in the field.
Fields of Study & Subjects
Single-cell and spatial transcriptomics
Immune responses and vaccinations
Immune cells in cancer
Publication details
- Journal / source
- European Journal of Immunology
- Publisher
- Wiley
- Volume
- 56
- Issue
- 4
- Pages
- e70185–e70185
- Publication date
- 1 April 2026
- Language
- EN