Undirected Primary C─H Functionalization of Alkanes via Hydrogen Atom Transfer

European Journal of Organic Chemistry 2026

View at publisher
Authors: Jie Qin, Jingjing Xia, Yating Zhao, Wujiong Xia
DOI: 10.1002/ejoc.202500887
Cited by: 2
References: 66

Abstract

Hydrogen atom transfer (HAT) which can produce radical intermediates from alkanes provides a strategy to achieve undirected C(sp 3 )‐H functionalization. Typically, primary CH bonds are the least reactive in HAT processes, compared to tertiary CH or activated benzylic CH. It is noteworthy that HAT‐mediated primary CH functionalization has recently been realized through the adjustment of various factors such as the catalyst or reagent design. This review summarizes recent advances in undirected primary CH functionalization via the HAT process. These examples will be discussed according to the HAT reagent. Reaction conditions, primary selectivity of various substrates, mechanism, and origin of the primary selectivity will be highlighted.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Oxidative Organic Chemistry Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
14
Publication date
9 March 2026
Language
EN