Light Driven Acid and Base Controlled Selective Synthesis of 3,4‐Dihydroquinoxalinones and Quinoxalinones via Cascade Cyclization of Aryl Diazoacetates With o ‐Phenylenediamines
Abstract
Herein, we report a direct, visible light‐induced synthesis of quinoxalinones from diazoacetates and o ‐phenylenediamines under mild reaction conditions. This versatile protocol enables the controlled selective synthesis of 3,4‐dihydroquinoxalinones or quinoxalinones by tuning of acid–base conditions. In mechanistic studies, both singlet oxygen ( 1 O 2 ) generation and single‐electron transfer plays a crucial role in quinoxalinones synthesis. The gram‐scale synthesis of 3,4‐dihydroquinoxalinone and quinoxalinone affords a moderate yield, which proves the practicability of the reaction conditions.
Fields of Study & Subjects
Cyclopropane Reaction Mechanisms
Radical Photochemical Reactions
Click Chemistry and Applications
Publication details
- Journal / source
- European Journal of Organic Chemistry
- Publisher
- Wiley
- Volume
- 29
- Issue
- 14
- Publication date
- 19 February 2026
- Language
- EN