The Difluorinative Acetonylation of Imidazopyridine Using Acetophenone and Selectfluor

European Journal of Organic Chemistry 2026 Open access

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Authors: Vijaya Rani Potluri, Saradhi Kalari, Akash U. Shinde, Shivani Maykalwar, Sagar Patil, Yeshwant Gajbhare, Avinash L. Puyad, Jagadeesh Babu Nanubolu, Haridas B. Rode
DOI: 10.1002/ejoc.202500995
Cited by: 0
References: 39

Abstract

We have developed an approach for the geminal difluorinative vicinal acetonylation of imidazo[1,2‐ a ]pyridines using selectfluor and aryl methyl ketones. This strategically designed nucleophilic addition of aryl methyl ketone to imidazopyridine was achieved through the geminal difluorination of imidazo[1,2‐ a ]pyridine using selectfluor. The method resulted in the formation of two CF bonds, one CC bond, and a quaternary stereocenter. This mild, efficient, and cost‐effective method offers a broad substrate scope and successfully extended to benzimidazothiazole derivatives.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Organic and Inorganic Chemical Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Volume
29
Issue
10
Publication date
15 February 2026
Language
EN