Photoinduced Palladium‐Catalyzed Intermolecular C(sp 3 )–H Carbonylation With CO, Amines, or Alcohols

European Journal of Organic Chemistry 2026

View at publisher
Authors: Wen‐Ao Li, Yi Liu, Xiao‐Yun Ruan, Hui Yu, Zhi‐Yong Han, Liu‐Zhu Gong
DOI: 10.1002/ejoc.202501092
Cited by: 3
References: 41

Abstract

A photoinduced, palladium‐catalyzed intermolecular C(sp 3 )–H carbonylation is developed for the direct synthesis of amides and esters from simple CH‐bearing substrates, carbon monoxide, and amines or alcohols. This protocol operates under remarkably mild conditions and exhibits excellent functional‐group tolerance. Diverse aromatic and aliphatic amines, as well as phenols and alcohols, are competent coupling partners, affording the corresponding amides and esters in good to excellent yields. The scope of CH‐bearing substrates extends to variously substituted toluenes, heteroaromatic methylarenes, amides, ethers, and cycloalkanes.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
11
Publication date
19 February 2026
Language
EN