Three‐Component Cascade Cyclization of Nitrones, Arylsulfonyl Azides, and Isocyanides for Synthesis of 5‐Imino‐1,2,4‐Oxadiazolidines

European Journal of Organic Chemistry 2026 Open access

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Authors: Yu‐Hang Mi, Zhi‐Yu Wang, Ya‐Hui Wang, KUO CHEN WANG, Zhang Ye, Ya‐Qi Yang, Xian‐Yi Huang, Shun‐Xin Zhang, Hong‐Wu Zhao
DOI: 10.1002/ejoc.202501126
Cited by: 1
References: 39

Abstract

Under the catalysis of Pd 2 (dba) 3 (10 mol%) and phosphoramidite (±)‐ L13 (20 mol%) in 1,2‐DCE at 80°C, the three‐component cascade cyclization of nitrones, arylsulfonyl azides, and isocyanides proceeded readily and delivered 5‐imino‐1,2,4‐oxadiazolidines in reasonable chemical yields. The chemical structure of one title compound has been confirmed by X‐ray diffraction analysis, and the others are suggested by inference.

Fields of Study & Subjects

Click Chemistry and Applications Synthesis of Tetrazole Derivatives Catalytic C–H Functionalization Methods

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
7
Publication date
16 January 2026
Language
EN