Cobalt‐Catalyzed Coupling of 1,3‐Enynes and Acrylates to Access Trisubstituted and Tetrasubstituted Olefins

European Journal of Organic Chemistry 2026 Open access

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Authors: Changliang Tan, Lina Ma, J. W. HUANG, Wenxin Lu, Qinglei Chong, Liang‐Hua Zou, Fanke Meng
DOI: 10.1002/ejoc.202501202
Cited by: 0
References: 56

Abstract

A general cobalt‐catalyzed oxidative cyclization strategy for the stereoselective synthesis of tri‐ and tetrasubstituted alkenes from readily available 1,3‐enynes is presented. This method employs an earth‐abundant cobalt catalyst and exhibits broad functional group tolerance, delivering the multisubstituted olefins with high regioselectivity and excellent Z / E control.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic Cross-Coupling Reactions Asymmetric Synthesis and Catalysis

Publication details

Journal / source
European Journal of Organic Chemistry
Volume
29
Issue
10
Publication date
15 February 2026
Language
EN