EDA Complex–Mediated C(sp 3 )–H Cross‐Dehydrogenative Coupling Enables Synthesis of Noncanonical α , β ‐Diamino Acids

Krishnakumar Sachidanandan; Cole Stenftenagel; Athul Joshy; Alexander M. Cluff; Sébastien Laulhé

doi:10.1002/ejoc.70356

EDA Complex–Mediated C(sp 3 )–H Cross‐Dehydrogenative Coupling Enables Synthesis of Noncanonical α , β ‐Diamino Acids

European Journal of Organic Chemistry 2026 Open access

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Authors: Krishnakumar Sachidanandan, Cole Stenftenagel, Athul Joshy, Alexander M. Cluff, Sébastien Laulhé

DOI: 10.1002/ejoc.70356

Cited by: 4

References: 40

Abstract

Nonproteinogenic α , β ‐diamino acids are key motifs in bioactive compounds. We report a photoinduced cross‐dehydrogenative coupling (CDC) of N ‐arylglycine derivatives with amides. This reaction proceeds via an electron donor–acceptor (EDA) complex that enables regioselective C(sp 3 )–C(sp 3 ) cross‐coupling, providing access to non‐canonical α , β ‐diamino acids from simple precursors.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Advanced Synthetic Organic Chemistry

Publication details

Journal / source: European Journal of Organic Chemistry
Publisher: Wiley
Volume: 29
Issue: 14
Publication date: 6 March 2026
Language: EN

References 40