Sulfoximidation of Aryl Alkenes via Oxidative CC Bond Cleavage

European Journal of Organic Chemistry 2026

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Authors: Parbin Rahman, Nikita Chakraborty, Himadri Boruah, Bhisma K. Patel, Kamal Krishna Rajbongshi
DOI: 10.1002/ejoc.70437
Cited by: 1
References: 52

Abstract

KI−mediated cross‐coupling between aryl alkenes and NH −sulfoximines under base‐ and metal‐free reaction conditions has been developed. This process involves the sequential oxidative cleavage of the CC double bond, followed by CN bond formation to synthesize biologically relevant N ‐acyl sulfoximines. This protocol features a broad substrate scope, excellent functional group compatibility, and high yields. Mechanistic investigations indicate the intermediacy of benzaldehyde‐derived as an acyl radical and highlight the crucial role of atmospheric oxygen as the oxygen source.

Fields of Study & Subjects

Synthesis and Catalytic Reactions Catalytic C–H Functionalization Methods Radical Photochemical Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
18
Publication date
3 April 2026
Language
EN