1,2,6‐Thiadiazin‐4‐ones: Robust Photocatalysts for the Green Aerobic Oxidation of Sulfides to Sulfoxides

European Journal of Organic Chemistry 2026 Open access

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Authors: Charikleia I. Karaousta, Stamatis K. Serviou, Chrysanthi K. Spyropoulou, Nikolaos Stavridis, Andreas S. Kalogirou, Panayiotis A. Koutentis, Christoforos G. Kokotos
DOI: 10.1002/ejoc.70448
Cited by: 1
References: 73

Abstract

The chemoselective oxidation of sulfides to sulfoxides is accomplished using a new family of photocatalysts, namely 1,2,6‐thiadiazin‐4‐ones. Utilizing a low catalyst loading (0.01 mol%), a 440 nm lamp as the irradiation source, and molecular oxygen as the oxidant, this rapid method is applicable to a broad range of alkyl‐aryl, dialkyl, and diaryl sulfides. Additionally, the method demonstrates practical relevance for the industrially significant synthesis of pharmaceutical compounds, including modafinil and sulforaphane.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Radical Photochemical Reactions Oxidative Organic Chemistry Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
18
Publication date
13 April 2026
Language
EN