Synthesis of Novel C ‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling

European Journal of Organic Chemistry 2026 Open access

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Authors: João A. F. Silva, Mônica F. Z. J. Toledo, Flávia Manarin, João H. de Araujo‐Neto, Milene M. Hornink, Hélio A. Stefani
DOI: 10.1002/ejoc.70536
Cited by: 1
References: 32

Abstract

We developed an efficient methodology for synthesizing C ‐acyl‐glycosyl sulfonamides via a carbonylative coupling reaction, using 1‐iodo‐glycals as substrates. A wide range of aromatic, heteroaromatic, and aliphatic sulfonamides was explored, employing Mo(CO) 6 as a safe, solid source of carbon monoxide gas. This approach enabled the preparation of novel glycosyl sulfonamides featuring a C ‐acyl‐linked framework under mild reaction conditions, achieving good to excellent yields.

Fields of Study & Subjects

Carbohydrate Chemistry and Synthesis Sulfur-Based Synthesis Techniques Catalytic Cross-Coupling Reactions

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
23
Publication date
9 May 2026
Language
EN