Facile Synthesis of Spiro Trifluoromethyl Pyrazolone–Pyrazole Derivatives Through a Base‐Mediated (3+2) Cycloaddition

European Journal of Organic Chemistry 2026

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Authors: Lingareddy Eeda, Susmitha Jadav, Sai Lokavarapu, Ravindra M. Kumbhare
DOI: 10.1002/ejoc.70556
Cited by: 1
References: 31

Abstract

Herein, we describe a 1,3‐dipolar (3 + 2) cycloaddition between hydrazonoyl chlorides and substituted trifluoromethyl pyrazolones for the synthesis of spirotrifluoromethyl pyrazolone–pyrazole derivatives under transition‐metal‐free conditions. This protocol delivers CF 3 ‐containing pyrazolone frameworks of notable synthetic and biological relevance. The cycloaddition enables the simultaneous formation of new CN and CC bonds, providing the desired spiro products in high yields. Moreover, the reaction demonstrates broad substrate compatibility, underscoring its practicality and synthetic utility.

Fields of Study & Subjects

Fluorine in Organic Chemistry Catalytic C–H Functionalization Methods Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
24
Publication date
25 May 2026
Language
EN