N‐Heteterocyclic Spiro‐Indenoid Frameworks Implemented Through [3 + 2]‐Spiro Annulation Involving Cyclic Ketimines and Alkynone or Its Structural Analog

European Journal of Organic Chemistry 2026

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Authors: Saiful Islam, Dwaipayan Das, Ghosh Sk, Aditi Gangopadhyay, Achintya Saha, Asish R. Das
DOI: 10.1002/ejoc.70688
Cited by: 1
References: 42

Abstract

An efficient, atom‐economic Ir(III) catalyzed [3 + 2]‐spiroannulation has been devised, allowing alynone/alkynoate/alkynamide/alkynoic acid to interact regioselectively at the C 2 N 1 bond rather than C 3  N 4 bond of 2‐aryl quinoxaline and cyclic ketimines, thus implementing the synthesis of biologically relevant spirocyclic indene fused N‐heterocyclic scaffolds under mild reaction condition. In silico studies have been attempted to predict the biological activity of the synthesized compounds involving computational target fishing strategy.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms

Publication details

Journal / source
European Journal of Organic Chemistry
Publisher
Wiley
Volume
29
Issue
31
Publication date
13 July 2026
Language
EN