Characterizing early behavioral and social–emotional problems in young children with SCN1A + Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia 2026 Open access

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Authors: Ingrid E. Scheffer, M. Scott Perry, Joseph E. Sullivan, Susana Boronat, J. W. Wheless, Andreas Brunklaus, Linda C Laux, Anup D. Patel, Colin Roberts, Dennis J. Dlugos, Deborah L. Holder, Kelly G. Knupp
+15 more Matt Lallas, Steven Phillips, Eric B. Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah A. Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico
DOI: 10.1002/epi.70127
Cited by: 1
References: 48

Abstract

OBJECTIVE: Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug-resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social-emotional skill development are limited. METHODS: We prospectively assessed behavioral and social-emotional problems in the ENVISION natural history study (NCT04537832) of children with DS associated with SCN1A pathogenic variants (SCN1A+ DS) enrolled at

Fields of Study & Subjects

Epilepsy research and treatment Pharmacological Effects and Toxicity Studies Functional Brain Connectivity Studies

Publication details

Journal / source
Epilepsia
Publisher
Wiley
Volume
67
Issue
5
Pages
2463–2479
Publication date
2 February 2026
Language
EN