Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane
Abstract
ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities. Among them, strictamine has posed a longstanding synthetic challenge due to its congested quaternary carbon center and complex polycyclic framework. Herein, we report a concise formal synthesis of (±)‐strictamine enabled by a silylium‐catalyzed intramolecular (4 + 2) annulation with a donor–acceptor cyclobutane, delivering the target in 13 steps from tryptamine.
Fields of Study & Subjects
Alkaloids: synthesis and pharmacology
Advanced Synthetic Organic Chemistry
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Helvetica Chimica Acta
- Publisher
- Wiley
- Volume
- 109
- Issue
- 4
- Publication date
- 30 January 2026
- Language
- EN