Efficacy, Effectiveness, and Safety of Treatment Regimens for Histoplasmosis and Tuberculosis Coinfection in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: A Systematic Review With Meta‐Analysis Protocol

Background and Aims: While previous publications have briefly pointed out a few alternative therapeutic interventions for the treatment of histoplasmosis and tuberculosis coinfections in patients with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), there are no reviews evaluating the efficacy, effectiveness, and safety of different regimens. Thus, this protocol outlines the approach for systematically reviewing and synthesizing the existing literature regarding the efficacy, effectiveness, and safety of different regimens for histoplasmosis and tuberculosis coinfection treatment in patients with HIV/AIDS. Methods: A systematic search will be conducted using PubMed, Embase, and Latin American and Caribbean Health Sciences Literature (LILACS) databases. Studies will be selected in two distinct stages, and data from selected studies will be extracted. Risk of bias will be assessed using the RoB 2, ROBINS-I, NOS, and JBI tools, depending on the type of study. Finally, the strength of the body of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Conclusions: The findings of this review may positively impact public health, stimulating the implementation of evidence-based practices and guiding the adoption of specific treatment protocols for patients with HIV/AIDS coinfected with histoplasmosis and tuberculosis in endemic regions.