Diagnostic Efficacy and Clinical Aspects of Panoramic‐View Versus Forward‐View Capsule Endoscopy for Suspected Small Bowel Bleeding: A Systematic Review and Meta‐Analysis

ABSTRACT Background and Aims CapsoCam provides a 360° panoramic‐view in capsule endoscopy (CE). This study aimed to conduct the initial systematic review and meta‐analysis on the diagnostic efficacy and clinical aspects of CapsoCam in patients with Suspected small bowel bleeding (SSBB), potentially comparing it to forward‐view CE. Methods A systematic search of PubMed, Embase, and Scopus databases was performed for human studies reporting outcomes of interest up to January 2025. Titles and abstracts were screened, and full‐texts were selected based on predefined inclusion criteria by two reviewers. The quality assessment used Joanna Briggs Institute checklist. Meta‐analysis used a random‐effects model with a 95% confidence interval (CI). Publication bias was evaluated using Egger and Begg's tests. A leave‐one‐out sensitivity analysis was performed. Results Five studies met the inclusion criteria. The meta‐analysis revealed no statistically significant difference in diagnostic yield between the two CE types in cases of SSBB ( p = 0.89, 95% CI: −0.08 to 0.09). Egger's test and Begg's test showed no significant publication bias. Comparative analysis between panoramic and forward‐view CEs demonstrated similar performance for small bowel transit time ( p = 0.58, 95% CI: −0.33 to 0.59), although evaluation time was significantly longer with CapsoCam ( p = 0.001, 95% CI: 0.42 to 1.60). The risk difference in completion rates was not statistically significant ( p = 0.91, 95% CI: −0.13 to 0.15). Subgroup analyses showed no significant differences in diagnostic yield or other outcomes between CapsoCam PLUS and SV‐1, or by study design. Conclusion Our analysis suggests that CapsoCam demonstrates comparable performance to forward‐view CE in terms of diagnostic reliability, clinical efficacy, and safety profile, except for reading time. However, the limited number of studies underscores the need for further research to validate CapsoCam's usability in routine clinical practice for SSBB patients compared to forward‐view CE.