Unusual case of ovarian basosquamous carcinoma metastatic disease from cutaneous primary malignancy

basosquamous carcinoma, case report, gynecologic oncology, immunotherapy, non-melanoma skin cancer, ovarian metastasis Metastases to the ovary most commonly originate from gastrointestinal adenocarcinomas, while primary cutaneous tumors are rare and typically melanoma.1 Basosquamous carcinoma (BSC), or metatypical basal cell carcinoma, is an uncommon variant of basal cell carcinoma (BCC) with squamous differentiation, representing approximately 2% of non-melanoma skin cancers. 2 Histologically, BSC demonstrates a transition zone between basaloid and squamoid cells, and typically expresses Ber-EP4 and cytokeratin 5/6 on immunohistochemistry. 2,3 Compared to other non-melanoma skin cancers, BSC has a greater propensity for local recurrence and distant metastases, frequently involving the brain, bone, lung, and liver.3 Here, we describe a case report of BSC with ovarian metastasis in a 38-year-old woman, 15 years after initial diagnosis of the disease.Case studies are not subject to institutional review board (IRB) review.The patient provided written informed consent as required by IRB policy.